Archives par mot-clé : thérapeutique

Toxicité de la triamcinolone ?

Après les anti-VEGF, et alors que nous l’utilisons couramment (cependant toujours hors AMM) depuis plusieurs années, avec de nombreuses publications à l’appui, la FDA vient de publier une alerte sur la toxicité de la triamcinolone d’un conservateur dans la préparation commerciale de triamcinolone (Kenalog), et déconseille son usage « off-label » :

February 7, 2007 — The US Food and Drug Administration (FDA) has approved safety labeling revisions to advise of the risk for […] toxicity associated with excessive exposure to the preservative in triamcinolone acetonide injectable suspension […]

Continuer la lecture de Toxicité de la triamcinolone ?

Alerte Lucentis

Lu ce matin sur Medscape :

Medscape Alerts : Lucentis Linked to Stroke Risk in Elderly

January 30, 2007 — Genentech, Inc, has warned healthcare professionals regarding the potential increased risk for stroke associated with use of ranibizumab (Lucentis) in the treatment of neovascular (wet) age-related macular degeneration in elderly patients.

The warning was based on interim data from an ongoing safety study (SAILOR) showing that the risk for stroke was significantly higher in patients receiving the recommended dose of ranibizumab (0.5 mg) compared with a 0.3 mg dose (1.2% vs 0.3%; P = .02) at an average follow-up of 230 days. Patients with a history of stroke appeared to be at increased risk for subsequent stroke, the company said.

Continuer la lecture de Alerte Lucentis